What is TB-500 and where does it come from?

TB-500 is a synthetic version of the active region of thymosin beta-4, a naturally occurring protein involved in tissue repair. Instead of the full protein, it's just the short peptide fragment researchers believe carries most of the repair-related activity. It's used as a research tool to study cell migration, wound healing and blood vessel growth.

What has research shown about TB-500?

Analytical studies have confirmed its chemical identity and developed methods to detect it in biological samples like equine plasma and urine. Because it's derived from thymosin beta-4, it's investigated in preclinical models for roles in cell movement, angiogenesis and tissue repair. All findings are research-stage and model-dependent — no human-use conclusions are supported.

Is TB-500 FDA approved?

No. TB-500 is not an FDA-approved drug and has no approved human or veterinary indication. The material sold here is supplied strictly for in-vitro and laboratory research use only — not for human consumption.

How is TB-500 different from thymosin beta-4?

Thymosin beta-4 is the full naturally occurring protein; TB-500 is a shorter synthetic peptide representing its active region. Researchers use the fragment because it's simpler to produce and study while retaining features tied to the repair activity of interest. Think of it as the working part of the larger molecule.

What is the molecular structure of TB-500?

TB-500 has the molecular formula C38H68N10O14 and a molecular weight of 889.02 g/mol, registered under CAS 885340-08-9. Its defining feature is that it's a short peptide sequence based on the active region of thymosin beta-4. Each lot is confirmed by LC-MS for identity and assayed at ≥99% purity by HPLC-UV.

TB-500

The tissue-repair peptide behind natural healing

99.46% pure on this exact lot, verified by an independent lab, not by us
Tested in America. Ships within 1 business day, stored frozen, stable at room temperature until you mix it
Retest it at any lab. If it doesn't match our report, every dollar back

$89/ 10mg vial

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99.46% pure on this exact lot, verified by an independent lab, not by us
Tested in America. Ships within 1 business day, stored frozen, stable at room temperature until you mix it
Retest it at any lab. If it doesn't match our report, every dollar back

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Certificate of analysis

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity
Raw chromatogram + mass confirmation attached
Signed off by the lab's Principal Chemist
Permanent archive — searchable by lot ID

or browse the lot archive

TB-500 · 10mgLot 3XWAU3Live

Purity by HPLC-UV

99.46%

Tested by: Freedom Diagnostics
Tested on: 14 Sept 2026
Net content: 9.91 mg

Contaminant screens

Heavy metalsEndotoxinsMicrobialSolvents

See all lab reports

Live batch data

Freedom Diagnostics

Independent analytical lab

Certificate of Analysis

RESULT · PASS

Lot 3XWAU3Verified

TB-500 10mg

HPLC purity

99.46%

Pass · Meets spec

Tested

14 Sept 2026

HPLC-UV + LC-MS

Analytical results

Identity (LC-MS)ConfirmedPASS

Net content9.91 mgPASS

HPLC Chromatogram

Main peak 99.46% · other 0.54%

Alex JohnsonPrincipal Chemist

Authentichain · Verified 44×

Cell migrationactin binding

Angiogenesisblood vessel growth

Tissue repairwound healing

How TB-500 works

Researchers study TB-500 through three main routes tied to how thymosin beta-4 supports repair.

Cell migrationactin binding

It's studied for helping cells move toward injured tissue by influencing actin, the internal scaffold cells use to crawl and reorganize.

Angiogenesisblood vessel growth

Preclinical work links it to the formation of new blood vessels, which could support tissue that's rebuilding after damage.

Tissue repairwound healing

It's investigated for its role in wound closure and remodeling, echoing what the parent protein does at injury sites.

For research use only. Mechanisms described reflect published preclinical and clinical literature.

Every batch we've tested

Anyone can show you one good report. Here is every batch of TB-500 we have ever released, newest first, each with its own signed report. Nothing hidden, nothing cherry-picked.

5 batches on record · latest tested 14 Sept 2026

All lab reportsEvery TB-500 batch, on one page.The full testing history with every signed report. No login, no email wall.See all lab reports

What the studies found

Published findings on this compound, each linked to its source. Animal and lab results are context, not claims about this product.

Skin woundsPreclinical

+61%

In rats with full-thickness skin wounds, thymosin beta-4, the parent protein of TB-500, sped new skin cover by 42% at day 4 and up to 61% at day 7 vs saline.

vs saline-treated wounds

J Invest Dermatol 1999 · rat study

Day 4+42%

Day 7+61%

Extra new skin over the wound vs saline

Brain injuryPreclinical

5.6×

In rats with brain injury, thymosin beta-4, the parent protein of TB-500, raised new nerve-cell formation 5.6-fold at the highest dose, vs 2.1-fold with saline, and improved maze learning.

vs 2.1× with saline

New neurons vs uninjured rats, at day 35

J Neurosurg 2012 · rat study

Tendon strengthPreclinical

+39%

In rats with repaired Achilles tendons, the synthetic thymosin beta-4 peptide known as TB-500 raised breaking strength to 37.4 N at four weeks, vs 26.9 N in controls.

vs 26.9 N in controls

Controls26.9 N

TB-50037.4 N

Median force to tear the tendon at four weeks

Jt Dis Relat Surg 2026 · rat study