What is CJC-1295 (no DAC) and where does it come from?

It's a synthetic peptide based on the first 29 amino acids of growth-hormone-releasing hormone (GHRH), often called Mod GRF (1-29). Researchers engineered small amino-acid substitutions into the natural sequence to make it more stable. It's studied as a tool for probing how the pituitary gland releases growth hormone.

What has research shown about how it works?

In preclinical models it binds the GHRH receptor and triggers a rapid, pulse-like release of growth hormone. Without the DAC (Drug Affinity Complex) modification, it clears from the system quickly, so it produces short bursts rather than a sustained elevation. This makes it useful for studying the body's natural GH rhythm.

Is CJC-1295 (no DAC) FDA approved?

No. CJC-1295 (no DAC) is not approved by the FDA for any use and is not a medicine. The material sold here is supplied strictly for in-vitro and laboratory research use only — not for human or veterinary use.

How does the "no DAC" version differ from CJC-1295 with DAC?

The DAC version carries a Drug Affinity Complex that lets it bind to blood albumin, greatly extending how long it stays active. The "no DAC" version lacks that add-on, so it acts and clears fast — giving researchers a short, sharp signal instead of a days-long elevation. The choice depends on whether a study needs pulsatile or prolonged GHRH activity.

What is the molecular structure of this peptide?

Its molecular formula is C152H252N44O42 with a molecular weight of about 3368.7 g/mol (CAS 863288-34-0). The defining feature is a 29-amino-acid GHRH backbone with stabilizing substitutions that resist enzymatic breakdown.

CJC-1295 (no DAC)

Short, sharp GH pulses in preclinical models

99.72% pure on this exact lot, verified by an independent lab, not by us
Tested in America. Ships within 1 business day, stored frozen, stable at room temperature until you mix it
Retest it at any lab. If it doesn't match our report, every dollar back

$69/ 5mg vial

$34.50 per vial with Buy 1, Get 1 Free

Buy 1, Get 1 Free — add 2 to cart, applied automatically

In stock

99.72% pure on this exact lot, verified by an independent lab, not by us
Tested in America. Ships within 1 business day, stored frozen, stable at room temperature until you mix it
Retest it at any lab. If it doesn't match our report, every dollar back

VISAAMEXPayPal

Secure checkout

All products currently listed on this site are for research purposes only.

Frequently bought together

Related laboratory supplies.

Reconstitution Solution · 3ml

Essential

GHK-Cu · 50mg

Melanotan II · 10mg

Add all (3)$97

Certificate of analysis

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity
Raw chromatogram + mass confirmation attached
Signed off by the lab's Principal Chemist
Permanent archive — searchable by lot ID

or browse the lot archive

CJC-1295 (no DAC) · 5mgLot J3SPECLive

Purity by HPLC-UV

99.72%

Tested by: Freedom Diagnostics
Tested on: 15 May 2026
Net content: 4.91 mg

Contaminant screens

Heavy metalsEndotoxinsMicrobialSolvents

See all lab reports

Live batch data

Freedom Diagnostics

Independent analytical lab

Certificate of Analysis

RESULT · PASS

Lot J3SPECVerified

CJC-1295 (no DAC) 5mg

HPLC purity

99.72%

Pass · Meets spec

Tested

15 May 2026

HPLC-UV + LC-MS

Analytical results

Identity (LC-MS)ConfirmedPASS

Net content4.91 mgPASS

HPLC Chromatogram

Main peak 99.72% · other 0.28%

Alex JohnsonPrincipal Chemist

Authentichain · Verified 29×

CJC-1295 (no DAC) 5mg — molecular specimen

GHRH receptorpituitary binding

Pulsatile releaseGH secretion

Enzyme resistancemodified sequence

How CJC-1295 (no DAC) works

CJC-1295 (no DAC) is studied as a growth-hormone-releasing hormone (GHRH) analog acting through three connected routes.

GHRH receptorpituitary binding

It docks onto the GHRH receptor on pituitary cells, the same signal the body uses to call for growth hormone.

Pulsatile releaseGH secretion

In preclinical models it prompts a short, sharp burst of growth hormone rather than a steady flat rise, echoing natural rhythm.

Enzyme resistancemodified sequence

Amino-acid swaps in the sequence slow enzyme breakdown, giving the peptide a longer active window than native GHRH in lab studies.

For research use only. Mechanisms described reflect published preclinical and clinical literature.

Every batch we've tested

Anyone can show you one good report. Here is every batch of CJC-1295 (no DAC) we have ever released, newest first, each with its own signed report. Nothing hidden, nothing cherry-picked.

3 batches on record · latest tested 15 May 2026

All lab reportsEvery CJC-1295 (no DAC) batch, on one page.The full testing history with every signed report. No login, no email wall.See all lab reports

What the studies found

Published findings on this compound, each linked to its source. Animal and lab results are context, not claims about this product.

Growth hormoneClinical

10×

In placebo-controlled trials in healthy adults, one injection of CJC-1295 with DAC, the long-acting form, raised growth hormone 2- to 10-fold, depending on dose, for 6 days or more.

vs levels before injection

JCEM 2006 · 2 placebo-controlled RCTs

Before injection1×

Lowest dose2×

Highest dose10×

Rise in mean blood GH after one injection

Baseline GHClinical

7.5×

In healthy young men, one injection of CJC-1295 with DAC, the long-acting form, raised baseline growth hormone 7.5-fold a week later and IGF-1 by 45%, with natural GH pulses unchanged.

vs the same men before

Trough GH7.5×

Mean GH+46%

IGF-1+45%

Change one week after a single injection

JCEM 2006 · overnight sampling study

Modified backbonePreclinical

4×

In rats, CJC-1295 with DAC, built on the same modified GRF(1-29) chain as this peptide, released 4 times more growth hormone over 2 hours than natural GRF(1-29).

vs natural GRF(1-29)

GRF(1-29)1×

CJC-12954×

Growth hormone released over 2 hours

Endocrinology 2005 · rat study