What is PT-141 and where does it come from?

PT-141, also called bremelanotide, is a small peptide and an active metabolite of Melanotan II, the tanning peptide. It's studied as a melanocortin receptor agonist — meaning it switches on receptors in the brain linked to arousal. Researchers find it interesting because it acts centrally, through the nervous system, rather than through blood vessels.

What has research shown about how PT-141 works?

Preclinical and pharmacology studies describe it as an agonist at melanocortin receptors, especially MC4R, in the central nervous system. In animal models, this activation has been associated with sexual arousal signaling in both males and females. These findings are research observations and are not claims about effects in people.

Is PT-141 FDA approved?

Bremelanotide is approved by the FDA under the brand name Vyleesi for a specific human indication. However, the material sold here is research-grade and is supplied strictly for in-vitro and laboratory research use only — not for human or veterinary use.

How does PT-141 differ from vascular-acting compounds?

The key difference is where it acts. Older arousal compounds work on the vascular system to change blood flow, while PT-141 is studied for acting on brain melanocortin receptors. That central mechanism is the main reason it became a distinct research target.

What is the molecular structure of PT-141?

Its molecular formula is C50H68N14O10 with a molecular weight of 1025.17 g/mol (CAS 189691-06-3). It's a cyclic heptapeptide, meaning a small ring-shaped chain of seven amino acids. This ring structure is a defining feature that separates it from its linear parent compound.

PT-141

A brain-first pathway to arousal, studied in labs

99.95% pure on this exact lot, verified by an independent lab, not by us
Tested in America. Ships within 1 business day, stored frozen, stable at room temperature until you mix it
Retest it at any lab. If it doesn't match our report, every dollar back

$59/ 10mg vial

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99.95% pure on this exact lot, verified by an independent lab, not by us
Tested in America. Ships within 1 business day, stored frozen, stable at room temperature until you mix it
Retest it at any lab. If it doesn't match our report, every dollar back

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Certificate of analysis

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity
Raw chromatogram + mass confirmation attached
Signed off by the lab's Principal Chemist
Permanent archive — searchable by lot ID

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PT-141 · 10mgLot D85YB7Live

Purity by HPLC-UV

99.95%

Tested by: Freedom Diagnostics
Tested on: 08 Oct 2026
Net content: 8.04 mg

Contaminant screens

Heavy metalsEndotoxinsMicrobialSolvents

See all lab reports

Live batch data

Freedom Diagnostics

Independent analytical lab

Certificate of Analysis

RESULT · PASS

Lot D85YB7Verified

PT-141 10mg

HPLC purity

99.95%

Pass · Meets spec

Tested

08 Oct 2026

HPLC-UV + LC-MS

Analytical results

Identity (LC-MS)ConfirmedPASS

Net content8.04 mgPASS

HPLC Chromatogram

Main peak 99.95% · other 0.05%

Alex JohnsonPrincipal Chemist

Authentichain

MC4Rreceptor agonist

Central pathwayCNS signaling

Dopamine linkneural circuits

How PT-141 works

Researchers study PT-141 as acting through three melanocortin-linked routes in the central nervous system.

MC4Rreceptor agonist

It activates the MC4 receptor in the brain, a switch preclinical models tie to sexual arousal signaling.

Central pathwayCNS signaling

Its effects are studied as central — driven by nervous-system signaling rather than changes in blood flow.

Dopamine linkneural circuits

Animal studies suggest melanocortin activation may feed into dopamine-related arousal circuits.

For research use only. Mechanisms described reflect published preclinical and clinical literature.

Every batch we've tested

Anyone can show you one good report. Here is every batch of PT-141 we have ever released, newest first, each with its own signed report. Nothing hidden, nothing cherry-picked.

6 batches on record · latest tested 08 Oct 2026

All lab reportsEvery PT-141 batch, on one page.The full testing history with every signed report. No login, no email wall.See all lab reports

What the studies found

Published findings on this compound, each linked to its source. Animal and lab results are context, not claims about this product.

Felt benefitClinical

58.3%

In the first of two 24-week trials in 1,267 premenopausal women with low sexual desire, 58.3% on bremelanotide reported benefit from the study drug, against 36.1% on placebo.

vs 36.1% on placebo

Obstet Gynecol 2019 · 2 phase 3 RCTs, n=1,267

Placebo36.1%

Bremelanotide58.3%

Reported benefit at 24 weeks, trial 301

Desire and distressClinical

+0.35

Across the two trials, desire scores rose 0.35 points more on bremelanotide than on placebo and distress about low desire fell 0.33 points more. Both differences were small.

vs placebo, 24 weeks

Desire score+0.35

Distress score−0.33

Difference from placebo at 24 weeks, both P<.001

Obstet Gynecol 2019 · 2 phase 3 RCTs

DistressClinical

−11.1

In a 12-week trial with data from 327 premenopausal women, distress about desire and arousal fell 11.1 points on bremelanotide, against 6.8 points on placebo.

vs −6.8 on placebo

Placebo−6.8

Bremelanotide−11.1

Change in sexual distress total score at 12 weeks

Womens Health 2016 · phase 2b RCT, n=327