Name: Melanotan II
Brand: Argo Peptides
SKU: ARG-MELANOTAN-II-10MG
Price: 49.00 USD
Availability: InStock

Question 1

What is Melanotan II and where does it come from?

Accepted Answer

Melanotan II is a synthetic cyclic peptide modeled on alpha-melanocyte-stimulating hormone (alpha-MSH), a natural signaling molecule in the body. It was originally developed at the University of Arizona as a research tool to study how the melanocortin system controls skin pigmentation. Researchers value it because it activates several melanocortin receptors at once, making it useful for probing pigment, appetite, and behavior pathways.

Question 2

What has research actually shown about Melanotan II?

Accepted Answer

In animal studies, the peptide produced visible skin darkening with little to no UV exposure by activating pigment-producing cells. Preclinical work also connects it to reduced food intake and changes in sexual behavior through brain melanocortin receptors. All of these findings come from cell and animal models and are hedged — they describe what studies observed, not guaranteed effects.

Question 3

Is Melanotan II FDA approved?

Accepted Answer

No. Melanotan II is not approved by the FDA for any use, and there is no approved drug based on it. A related but structurally different peptide, afamelanotide (Scenesse), is approved for a rare light-sensitivity condition, but that is not the same compound. The material sold here is strictly for in-vitro and laboratory research use only — not for human or veterinary use.

Question 4

What is the molecular structure of Melanotan II?

Accepted Answer

Melanotan II has the molecular formula C50H69N15O9 and a molecular weight of 1024.19 g/mol. Its defining structural feature is that it is a cyclic (ring-shaped) peptide, which makes it more stable and receptor-selective than the linear alpha-MSH it's based on. Its CAS number is 121062-08-6.

Question 5

How does Melanotan II differ from afamelanotide?

Accepted Answer

Both are melanocortin-active peptides, but afamelanotide (Melanotan I) is a linear peptide that mainly targets the MC1R pigment receptor. Melanotan II is cyclic and hits multiple receptors — MC1R, MC3R, and MC4R — which is why research on it spans pigment, appetite, and behavior rather than pigment alone. That broader activity makes it a versatile research tool but also less selective.

Melanotan II

Every vial ships with its own report

How Melanotan II works

PigmentationMC1R agonist

AppetiteMC4R pathway

BehaviorMC3R / MC4R

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What the studies found

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