What is KPV and where does it come from?

KPV is a tripeptide made of three amino acids: lysine, proline, and valine. It's the C-terminal fragment (positions 11-13) of alpha-MSH, a naturally occurring hormone known for anti-inflammatory activity. Researchers study KPV because it keeps much of that anti-inflammatory action in a far smaller, simpler molecule.

What has research shown about KPV?

In mouse models of colitis, studies report that KPV reduced colon inflammation and disease severity by lowering inflammatory signaling. Cell studies suggest it enters cells through the PepT1 transporter and blocks NF-κB, a switch that activates inflammatory genes. These are preclinical findings — how or whether they translate to humans has not been established.

No. KPV is not an FDA-approved drug and has no approved human indication. The material sold here is a research-grade compound supplied strictly for in-vitro and laboratory research use only — not for human or veterinary use.

How does KPV differ from full-length alpha-MSH?

Alpha-MSH is a 13-amino-acid hormone with both anti-inflammatory and pigment-stimulating (melanocyte) activity. KPV is just its final three residues, and research suggests it retains the anti-inflammatory activity while dropping much of the pigment-related signaling. Its small size also makes it easier to study and more stable.

What is the molecular structure of KPV?

KPV has the molecular formula C16H30N4O4 and a molecular weight of 342.44 g/mol (CAS 67727-97-3). Structurally it's a simple linear tripeptide — lysine-proline-valine — which is what gives it easy cell uptake and handling stability.

KPV

A tiny tripeptide with big anti-inflammatory potential

99.21% pure on this exact lot, verified by an independent lab, not by us
Tested in America. Ships within 1 business day, stored frozen, stable at room temperature until you mix it
Retest it at any lab. If it doesn't match our report, every dollar back

$69/ 10mg vial

$34.50 per vial with Buy 1, Get 1 Free

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99.21% pure on this exact lot, verified by an independent lab, not by us
Tested in America. Ships within 1 business day, stored frozen, stable at room temperature until you mix it
Retest it at any lab. If it doesn't match our report, every dollar back

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Certificate of analysis

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity
Raw chromatogram + mass confirmation attached
Signed off by the lab's Principal Chemist
Permanent archive — searchable by lot ID

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KPV · 10mgLot XU9VW4Live

Purity by HPLC-UV

99.21%

Tested by: Freedom Diagnostics
Tested on: 05 Oct 2026
Net content: 8.17 mg

Contaminant screens

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Live batch data

Freedom Diagnostics

Independent analytical lab

Certificate of Analysis

RESULT · PASS

Lot XU9VW4Verified

KPV 10mg

HPLC purity

99.21%

Pass · Meets spec

Tested

05 Oct 2026

HPLC-UV + LC-MS

Analytical results

Identity (LC-MS)ConfirmedPASS

Net content8.17 mgPASS

HPLC Chromatogram

Main peak 99.21% · other 0.79%

Alex JohnsonPrincipal Chemist

Authentichain · Verified 16×

NF-κB blockinflammatory switch

Cell entryPepT1 transport

Cytokine calmingimmune signaling

How KPV works

KPV is studied to act through three connected routes that together quiet inflammation.

NF-κB blockinflammatory switch

KPV is studied to interfere with NF-κB, the signaling switch that turns on inflammatory genes, lowering output of pro-inflammatory molecules.

Cell entryPepT1 transport

Research suggests KPV hitches a ride into cells through the PepT1 transporter, letting it work from the inside rather than only at the cell surface.

Cytokine calmingimmune signaling

Preclinical models point to reduced production of inflammatory cytokines like TNF-α and IL-8 in immune and gut-lining cells.

For research use only. Mechanisms described reflect published preclinical and clinical literature.

Every batch we've tested

Anyone can show you one good report. Here is every batch of KPV we have ever released, newest first, each with its own signed report. Nothing hidden, nothing cherry-picked.

4 batches on record · latest tested 05 Oct 2026