What is Epithalon and where did it come from?

Epithalon is a synthetic tetrapeptide — just four amino acids, Ala-Glu-Asp-Gly — originally derived from a pineal gland peptide extract studied in Russian gerontology research. Scientists care about it because in preclinical work it appeared to act on telomeres and telomerase, the machinery cells use to keep their chromosome caps from wearing down with age.

What has research actually shown about Epithalon?

In cultured human cells, studies reported it activated telomerase and lengthened telomeres. In aged-mouse studies, it was linked to longer average lifespan versus untreated controls. These are preclinical findings in cells and animals — they describe what researchers observed, not any established effect in people.

Is Epithalon FDA approved?

No. Epithalon is not approved by the FDA for any use and there is no approved drug product based on it. The material sold here is a research chemical supplied strictly for in-vitro and laboratory research use only — not for human or veterinary use.

How is Epithalon different from a full-length protein?

It's a minimal four-residue peptide, not a large protein, which makes it easy to synthesize and study as a defined molecule. Its small size is part of why researchers hypothesize it can interact directly with DNA and regulatory pathways, unlike bulkier proteins.

What is the molecular structure of Epithalon?

Its molecular formula is C14H22N4O9 with a molecular weight of 390.35 g/mol (CAS 307297-39-8). The defining feature is its four-amino-acid sequence, Ala-Glu-Asp-Gly, a linear tetrapeptide with no complex folding.

Epithalon

The telomere peptide that extended lifespan in aged mice

99.90% pure on this exact lot, verified by an independent lab, not by us
Tested in America. Ships within 1 business day, stored frozen, stable at room temperature until you mix it
Retest it at any lab. If it doesn't match our report, every dollar back

$89/ 50mg vial

$44.50 per vial with Buy 1, Get 1 Free

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In stock

99.90% pure on this exact lot, verified by an independent lab, not by us
Tested in America. Ships within 1 business day, stored frozen, stable at room temperature until you mix it
Retest it at any lab. If it doesn't match our report, every dollar back

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Certificate of analysis

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity
Raw chromatogram + mass confirmation attached
Signed off by the lab's Principal Chemist
Permanent archive — searchable by lot ID

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Epithalon · 50mgLot FWTRH5Live

Purity by HPLC-UV

99.90%

Tested by: ILS Laboratories
Tested on: 22 Oct 2026
Net content: 52.72mg

Contaminant screens

Heavy metalsEndotoxinsMicrobialSolvents

See all lab reports

Live batch data

ILS Laboratories

Independent analytical lab

Certificate of Analysis

RESULT · PASS

Lot FWTRH5Verified

Epithalon 50mg

HPLC purity

99.90%

Pass · Meets spec

Tested

22 Oct 2026

HPLC-UV + LC-MS

Analytical results

Identity (LC-MS)ConfirmedPASS

Net content52.72mgPASS

HPLC Chromatogram

Main peak 99.90% · other 0.10%

Alex JohnsonPrincipal Chemist

Authentichain · Verified 5×

Telomeraseenzyme activation

Gene regulationDNA binding

Pineal axismelatonin rhythm

How Epithalon works

Researchers study three distinct routes for how Epithalon may act.

Telomeraseenzyme activation

It's studied for switching on telomerase, the enzyme that rebuilds the protective caps on chromosome ends in dividing cells.

Gene regulationDNA binding

The short peptide is thought to bind DNA and influence which genes are turned on, a route probed in cell studies.

Pineal axismelatonin rhythm

Because of its pineal-extract origin, it's investigated for effects on melatonin output and circadian timing in animal models.

For research use only. Mechanisms described reflect published preclinical and clinical literature.

Every batch we've tested

Anyone can show you one good report. Here is every batch of Epithalon we have ever released, newest first, each with its own signed report. Nothing hidden, nothing cherry-picked.

3 batches on record · latest tested 22 Oct 2026

All lab reportsEvery Epithalon batch, on one page.The full testing history with every signed report. No login, no email wall.See all lab reports

What the studies found

Published findings on this compound, each linked to its source. Animal and lab results are context, not claims about this product.

TelomerasePreclinical

26×

In a British lab study, three weeks of epitalon raised telomerase, the enzyme that rebuilds telomeres, fourfold in normal human connective-tissue cells and 26-fold in normal breast cells.

vs untreated cells

Biogerontology 2025 · human cell study

Untreatedbaseline

Fibroblast cells4×

Breast cells26×

Telomerase activity after 3 weeks, vs untreated

SurvivalClinical

−28%

In a 12-year randomized trial in elderly heart patients, those given epithalamin, the pineal extract epitalon was modeled on, had 28% fewer deaths than controls.

vs control group, same base care

Controlbaseline

All deaths−28%

Heart deaths2× lower

Deaths after 12 years, control group set to 100

Bull Exp Biol Med 2006 · 12-year RCT

MelatoninClinical

1.7×

In middle-aged people, epitalon raised urine levels of melatonin's main breakdown product 1.7-fold, a standard marker of the body's melatonin output.

fold rise in urine marker

Without epitalonbaseline

With epitalon1.7×